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Mid‐luteal progesterone and ongoing pregnancy Lessons learned from GnRHa trigger GnRHa trigger Study Progesterone OPU + 7 (nmol/l) Positive HCG per ET % Pregnancy loss % Clinical pregnancy % Luteal phase support Humaidan et al., 2005 39±30 29 (14/48) 79 (11/14) 6 (3/48) vaginal gel progesterone (90 mg/day) Humaidan et al., 2010 74±52 48 (63/130) 21 (13/63) 38 (50/130) 1500 IU hCG on the day of OPU plus vaginal gel progesterone 90 mg per day Humaidan et al., 2013 440±25 43 (47/110) 9 (4/47) 39 (43/110) 1500 IU hCG on day of OPU plus OPU+5 days plus vaginal gel progesterone 90 mg/day P4 EPL PR Optimal 150 - 250 nmol/l (47-79 ng/ml) 42% 54% 45% 38% 50% of patients outside optimal window... Thomsen et al., 2018 64 PRECONGRESS COURSE 09 I VIENNA, AUSTRIA – 23 JUNE 2019 67