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Mesonephric cell migration in XY – E11.5 and 16.5 absolutly essential for testis cord formation
Mesonephric‐derived cells: ‐ enothelial
‐ perivascular
‘sandwich culture’ experiments
Chemoattractants from XY gonad: PDGFα, NFG, neutropin 3 (NT3), AMH, activin A and B
Migration prior to E11.5 (untill E12.5) is required for cord formation in XY gonads Induction of migration into XX gonads results in Sertoli cell diff and cord formation Cell migration is required for the maintenance of Sertoli cell differentiation
Yao et al. 2003
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