Page 43 - Eshre 2018
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 Male germ cell differentiation: niche (males)?
• XY & niche is the problem: Sertoli cells-only syndrome
• Male with normal testis, no germ cells (male infertility)
• Difficult to distinguish from direct effect on niche or germ cells
• In vitro human model to distinguish effects on niche or germ cells
   Chuva de Sousa Lopes   15
  Male germ cell differentiation: germ cells?
 Saitou and Miyauchi, Cell Stem Cell 2016
Chuva de Sousa Lopes   16
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