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Trials in pregnancy complications
• Unexplained recurrent miscarriage
• Antiphospholipid syndrome (APS)
• Women with inherited thrombophilia
• Late pregnancy complications
• High‐risk women
Many trials without a no treatment or placebo
Outcomes
comparator
• Live birth
• (Recurrence of) preeclampsia, HELLP, SGA, abruption
Observational research for interventions
• Regression to the mean
• Placebo effect
• Tender loving care
• 86%vs33%livebirth
Stray-Pederson, Am J Obstet Gynecol 1984
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