Page 118 - PCC05

LMWH
UFH
Heparins + aspirin vs aspirin alone in APS and recurrent miscarriage
LMWH trials show no benefit!
2017 Update Cochrane review, in preparation
HepASA trial
Dalteparin + aspirin versus aspirin alone
Women with ≥ 2 pregnancy losses (< 32 weeks), n=88
Antiphospholipid antibody syndrome (n=44)
Inherited thrombophilia (n=19), or Antinuclear antibodies (n=30)
No other explanations
No effect of aspirin and LMWH
Live birth rate 78% and 79%
Laskin, J Rheumatol 2009
Page 112 of 135
118