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Hyperemesis Gravidarum
Is not morning sickness
Is not diagnosed by ketonuria
Is associated with low vitamin B1 (Wernicke)
Is associated with an (small) increase in poor perinatal outcome
Defined as
- Severe vomiting and nausea in pregnancy
- No evident explanation (eg appendicitis, gastroenteritis, malignancy)
- Poor intake
- Weight loss
- Electrolyte imbalance
- Dehydration
http://www.comet-initiative.org/studies/details/805
Hyperemesis patients have low nutritional intake
Variable
Hyperemesis
Controls
P-value
Energy intake (kcal)
990 (95% CI 709-1233)
1652 (1558-1880)
<0.001
443 (SD+343)
1813 (+714)
<0.0005
Protein (g)
27.6 (17.9-37.7)
63.2 (51.1-69.1)
<0.001
11.6 (+12.3
62.9 (+25.9)
<0.0005
Fat (g)
36.1 (21.8-47.2)
66.3 (47.6-77.2)
<0.001
14.7 (+17.5)
69.0 (+30.2)
<0.0005
Carbohydrates (g)
147.2 (98.7-165.0)
195.4 (167.1-226.7)
0.001
64.5 (+41.9)
229 (+112)
<0.0005
Page 63 of 135
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E Birkeland, PLoS One, 2015 Van Stuijvenberg, AJOG, 1995
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PRECONGRESS COURSE 05 I BARCELONA, SPAIN – 1 JULY 2018 69
PresentationAMC.pptx PresentationAMC.pptx
