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Other Data on Letrozole Anomaly Rates
 Overall, congenital malformations were found in 5 out of 171 (2.9%) babies in natural conception group and 5 out of 201 babies in the letrozole group (2.5%) and in 10 of 251 babies in the CC group (3.9%).
– Sharma et al, PLOS one, 2014 (Single Center)
 Major congenital anomalies were similar between the two groups (natural cycle ART, N = 3,371 1.5% vs letrozole ART, N = 792) 1.9%, aOR, 1.24, 95% CI, 0.64-2.40, P = 0.52)
– Tatsumi et al, Hum Reprod, 2016 (Japan ART Registry- 2 years)
2012
Birth Defect Rate from Assisted Conception
Birth Defect Rate from Pregnancies without Assisted Conception
Adjusted Odds Ratio of Birth Defect with Assisted Conception (95% CI)
8.3%
5.8%
1.28 (95% CI, 1.16 to 1.41).
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