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PCOS definition
(Rotterdam 2003 & NIH 2013 Consensus)
Azziz Nestler Oligo- or Amenorrhea
Dahlgren Hom2boutrogf 3 !!!!
Wild
Tan
Dunaif
Taylor Pugeat
Laven Diamanti
(cycle length > 35 days)
Oligo- or Amenorrhea
Rule out:
Bouchard Pasquali
Wild
Hyperandrogenism
Filicori Magoffin
(hirsutism and / or FAI >
Hyperandrogenism
Hyperprolactimemia
Dewailly Ibanez
Norman
Legro
Balen
Franks
PCOM
Strauss
4.5)
(Clinical or Biochemical)
Devoto
PCOM
NCAH
Cushing’s syndrome Androgen Secreting Neoplasm
Acromegaly
( > 12 follicles, 2 – 9 mm, in one or both ovaries and /or
ovarian volume > 10 mL)
PCOS
Table 1 Phenotype groups: NIH / Rotterdam / AES
Features
N
%
A
OD + HA + PCOM
813
52
B
OD+ HA
169
10
C
HA + PCOM
16
3
D
OD + PCOM
560
35
HA= Clinically or biochemically proven hyperandrogenemia, OD= Ovulatory dysfunction, PCOM= Poly cystic
ovaries * Phenotype groups accord
arlatzis
F
in
a
u
s
e
r
T
g
to
Az
zi
z, 200
6
Hyperandrogenism & PCOS
(Laven et al., Obst Gyn Survey, 2002; Burgers et al., Fertil Steril, 2011)
FAI distribution in women with PCOS 200
100
0
0 8 16 24 32 40 Free Androgen Index (FAI
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