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Take Home Messages
 AndrogensarepartofthediagnosticcriteriaoftheRotterdamConsensus
 Androgens are increased in most women with PCOS. Androgens generally increase during puberty and decrease gradually
thereafter
 Androgen serum levels are influenced by several factors amongst other by OCP use
 Androgen levels are show considerable genetic heritability
 Genetic analysis did not reveal a crucial role for androgens as the primary driver for PCOS
 Androgens serum levels as well as the Free Androgen Index (FAI)are associated and are predictive for treatment outcome
 AndrogensarenotassociatedwithlongtermhealthissuesasCardioVascularDisease
 Anti-MüllerianHormone(AMH)isprobablythedriverofPCOSandelevatedandrogensareadirectsubsequentresultofthe perturbed GnRH excretion from the hypothalamus
 Hyperandrogenism is not the villain it is AMH
Acknowledgements
Netherlands
 Jits Schipper
 Olivier Valkenburg
 Sharon Lie Fong
 Yvonne Louwers
 Wendy van Dorp
 Sam Schoenmakers
 Andre Uitterlinden 
 Jan Hoeijmakers
 Wilbert v/d Meij
 Axel Themmen
 Jenny Visser
 Bart Fauser
 Nils Lambalk
Thank you for your attention and
Happy to take any questions
ReproGen consortium
 CHARGE consortium
 i-PCOS Consortium
 DeCode
 Stephen Franks
 Mark McCarthy
 Cecilia Lindgren
 John Perry
 Ricardo Azziz
 Mark Goodarzi
 Unur Styrkadottir
 Corinne Welt
 Andrea Dunaif
 Richard Legro
International
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PRECONGRESS COURSE 07 I BARCELONA, SPAIN – 1 JULY 2018 55