Page 50 - PCC08
P. 50
Genomic DNA Methylation
Germ Cell Development Preimplantation Development
Denomme & Mann, Reproduction 2012
Primordial Germ Cell
Primordial Germ Cell
To investigate the methylome of aneuploid blastocysts to understand differences in implantation potential.
Specific aneuploidies chosen based on implantation potential: 7, 11, 15, 21, and 22
• +7 and +11: likely to result in implantation failure
• +15 and +22: able to implant but result in miscarriage
• +21: implant and will result in miscarriage, still birth, or live birth
Page 44 of 102
McCallie et al, 2016 Plos One
50
Methylation
Fertilization
