Page 72 - PCC08

Genetic Variation and Age of Menopause
(Stolk et al., Nature Genetics, 2009)
 Age at Menopause varies widely between women
 Age at Menopause is not dependent on nutritional status
 Menopause shows no decennial and centennial trends
 Early Menopause is associated with several adverse health sequelae such as:  Infertility
 Sexual Dysfunction
 Cognitive dysfunction
 Cardiovascular disease
 Osteoporosis
 Decreased Longevity as well as General Health
 Age at Menopause is estimated to attributable for 50% to genetic factors in family and twin studies
ESHRE Pre Congres Course 8:
Genes Involved in Menopause and POI
GENETICS OF MENOPAUSE
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