Page 78 - PCC08

DNA Damage, Ageing and Cancer
(Hoeijmakers JHJ, NEJM 2009)
DNA Damage, Ageing and Cancer
(Hoeijmakers JHJ, NEJM 2009)
The trichothiodystrophia (TTD) Phenotype
 premature ageing
 osteoporosis and kyphosis  osteosclerosis
 early greying
 cachexia
 infertility
 reduced life-span
TTD DNA repair defective mice are extremely sensitive to oxidative DNA damage.
Page 72 of 102
78