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Take Home Messages
 Genes affecting ovarian function seem to play a role in DNA maintenance and DNA repair and as such are involved in both somatic cell and germ line ageing.
 Nearly none of genetic variants can be associated with known processes that are important during folliculogenesis and ovulation as well as for ovarian (dys)function. However, most SNP’s are referring to genes involved in DNA repair as well as DNA maintenance and replication, Energy metabolism (mitochondrial competence) and immunology
 This suggest either an extra ovarian regulatory mechanism or that the gonad uses DNA repair mechanisms similar to those used for damage repair of the soma
 Ageing of the soma seems to be the predominant driver for loss of ovarian function. In case the soma becomes too old it is of no use to invest in the germ cell line and therefore you are not allowed to reproduce anymore !!!! Hence you switch your ovary off
 Menopause is related to Reproductive Success and Reproductive Health which in turn is associated with Longevity. Similarly Reproductive Disorders seem to be associated with a decreased health status.
 Hence a compromised ovarian function might not only indicate decreased fertility but is also constitutes an early marker for and disease susceptibility later on in life
 The latter might provide us with early makers for Non Communicable Diseases (NCD’s) for which preventive strategies should be developed.
Acknowledgements
Netherlands
 Jits Schipper
 Olivier Valkenburg
 Sharon Lie Fong
 Yvonne Louwers
 Wendy van Dorp
 Sam Schoenmakers
 Andre Uitterlinden 
 Jan Hoeijmakers 
 Wilbert v/d Meij 
 Axel Themmen 
 Jenny Visser 
 Bart Fauser
 Nils Lambalk
Thank you for your attention and
Happy to take any questions
International
ReproGen consortium CHARGE consortium i-PCOS Consortium DeCode
Stephen Franks
 Mark McCarthy
 Cecilia Lindgren
 John Perry
 Ricardo Azziz
 Mark Goodarzi
 Unur Styrkadottir
 Corinne Welt
 Andrea Dunaif
 Richard Legro
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