Page 134 - PCC11

▶
▶
Infertility causes
THE ABC OF NEXT GENERATION SEQUENCING-BASED GENETIC DIAGNOSTICS IN INFERTILITY
LEARNING OBJECTIVES
Genetic causes of male & female infertility
▶ Chromosomal
▶ Molecular (DNA/gene level) 5%
Genetic tests for male & female infertility ▶ Chromosomal
▶ Molecular (DNA/gene level)
25%
10%
30%
30%
▶ NGS based molecular tests for female infertility
▶ Approach ▶ Results
▶ Conclusions
Female
Male Combined
Unexplained
Other
• Gene panel
• Trio exome analysis • Functional study
Page 128 of 155
The ABC of next generation sequencing-based genetic diagnostics in fertility
8-6-2018 | 3
GENETIC CAUSES OF INFERTILITY
MALE & FEMALE
The ABC of next generation sequencing-based genetic diagnostics in fertility
8-6-2018 | 4
134