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Learning Objectives
1. InheritanceofmitochondrialDNAandreproductive consequence for women with a pathogenic mutation
2. Preimplantationgeneticdiagnosisvspronucleartransfer for women with a pathogenic mutation
3. Patient/donortreatmentpathway
4. Technicalchallengesofthepronucleartransfertechnique
5. Trainingandcompetencyoftheembryologist
Mitochondria
- Mitochondria produce energy in the form of ATP
- Provides 90% of the cells energy requirements
- Mitochondria contain own DNA (mtDNA) - Multiple copies of mtDNA in each cell
- Encodes 37 genes
-mitochondrial gene-encoded proteins have a key role in energy production
- mtDNA can have mutations
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