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Interpretation
Consistency of result
• How similar are the results?
Likelihood of bias
• Publication and reporting biases
Does the result make sense?
• Biological plausibility
Applicability
Limitations of meta‐analysis
Limitations:
• GIGO - grade the included studies
• Heterogeneity / generalisability
− criteria for selection of studies important
− combining studies may not be appropriate
• publication bias
Caution:
• outdating of information
– 50% within 5 years
– 25% within 2 years
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