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Blastocyst versus cleavage stage
embryo transfer: a meta analysis
(Martins et al., 2016)
• Most recent metanalysis:
• 12 studies = 1200 women
• No significant difference in live birth/ongoing pregnancy in both single transfer or cumulative live birth rate.
• (RR 1.11, 95% CI 0.92‐1.35)
• Low quality evidence
The objective was to have a single birth at term. However, new data showed that transfers on blastocyst stage are associated with higher risk of preterm labor, large for gestational age babies, monozygotic twins and altered sex ratio (Maheshwari 2016)
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