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The Mitochondrial Bottleneck
• Believed that a mitochondrial bottleneck restricts the number /type entering the gametic pool probably at the primordial GC
• Either stochastic (random) or tissue specific selection
• Replication not linked to mitosis – can be rapid duplication between cell divisions
• Native mitochondria not preferentially selected for over acquired (foreign)
mitochondria (Lee et al 2012; Yamada 2016)
100+ copies
100,000s copies copies / cell reduce
Many years
. Understanding and avoiding mitochondrial genetic diseas
Recent Advances in Mitochondrial Disease Lyndsey Craven, Charlotte L. Alston, Robert W. Taylor, and Doug M. Turnbull Annual Review of Genomics and Human Genetics 2017 18:1, 257-275
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PRECONGRESS COURSE 15 I BARCELONA, SPAIN – 1 JULY 2018 85
