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Testing Nuclear DNA is Different from testing Mitochondrial DNA
Nuclear DNA
Bad gene present or not present
Mitochondrial DNA (mtDNA)
unaffected
Less likely
to be affected
affected
More likely
to be affected
Mixture of mutated and normal mtDNA (heteroplasmy) in each cell
Disease may not be eliminated but probability reduced
Adapted from : Smeets et al Preventing transmission of mtDNA disorders using prenatal or preimplantation genetic diagnosis. Ann. N.Y. Acad. Sci. 1350 (2015) 29–36
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