Page 89 - PCC15
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1. Patient’s egg with abnormal mitochondria fertilised with partner’s sperm
2. Patient’s zygote with abnormal mitochondria
3. Patients’ pronuclei removed from zygote and transferred to enucleated egg, which has normal mitochondria.
Donated egg fertilised Normal mitochondria
2nd polar body
Zygote enucleated
Normal mitochondria
1st polar body
+ fusogen
What are the risks?
4. Cleaving embryo with normal mitochondria and a maternal and paternal genome
Possibility of Carryover and Reversion
PNT = pronuclear transfer
Zygote
Normal mitochondria
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PRECONGRESS COURSE 15 I BARCELONA, SPAIN – 1 JULY 2018 89
