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Recommendations to HFEA of the independent scientific advisory Committee 2016
Since PGD is licensed for use in mtDNA disorders and often results in embryos being transferred with significant levels of mutant mtDNA (but is still useful as a risk reduction strategy), PNT and MST is safe enough to be used in a similar way as a risk reduction strategy where PGD is in appropriate or unlikely to work.
Cautious, specific implementation with long-term follow-up
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Recommendations to HFEA of the independent scientific advisory Committee 2016
Cautious, specific implementation with long-term follow-up
Patients must be fully informed of the theoretical risk and PND offered
Patients should be encouraged to take part in long-term follow-up Haplotype matching should be considered if feasible
The panel could not recommend its use be extended to otherwise healthy individuals with fertility problems but not genetic disease
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