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What factors might be added in OT
Cohen et al MHR 1988
1. Mitochondria from the donor supplement pool of mitochondria 2. Internal pool of inherited (maternal) mRNAs may be boosted
3. Other organelles (ribosomes, proteins, spindle organizing units) 4. Specific consequences by altering a single mechanism
e.g. change in the polarization of mitochondria
“The transfer of small amounts of donor ooplasm (5–15%) probably includes mRNAs, proteins, mitochondria, as well as other factors and organelles”.
“ The supposition that this procedure is a form of genetic manipulation or gene therapy confuses the issue, even if only justifiable from a puritan point of view, since it involves incorporation of foreign ribosomal DNA, mRNA and mtDNA.”
“ In our opinion, the presented technology is highly experimental and it would
be wise to delay its widespread medical application until further studies in animal models and donated human material indicate the best approaches”.
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