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Mitochondrial replacement or augmentation
Some difficult questions?
• Do we really have evidence that defective mitochondria are
the cause of embryonic delay or IVF failure?
If most embryo failure is due to meiotic aneuploidy, how does mitochondrial replacement help this?
• Is the risk of some unexpected heteroplasmy after OI worth the risk?
• How do we justify replacement of the whole mtDNA genome with donor mtDNA to treat infertility?
• If we do so, should we limit effects by replacing males only?
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