Previous highlights 2014

Highlights November/December 2014

Fresh versus frozen embryo transfer: backing clinical decisions with scientific and clinical evidence
in Hum. Reprod. Update (November/December 2014) 20 (6): 808-821. doi: 10.1093/humupd/dmu027

Jemma Evans et al.

In the latest issue of Human Reproduction Update, Jemma Evans and colleagues discuss the clinical validity of frozen embryo transfer (FET) as an alternative to fresh embryo transfer. Evans et al. summarise existing literature, indicating that FET is associated with a reduction in the incidence of ovarian hyperstimulation, a better pregnancy rate and improved neonatal outcome. The data shown derive from an evidence-based approach and may influence the future clinical approach to IVF.

Highlights September/October 2014

Clinical outcomes following selection of human preimplantation embryos with time-lapse monitoring: a systematic review in Hum. Reprod. Update (September/October 2014) 20 (5): 617-631. doi: 10.1093/humupd/dmu023

Daniel J. Kaser and Catherine Racowsky

Time Lapse Monitoring (TLM) is a novel technique allowing semi-quantitative evaluation of embryo morphology and early developmental processes. In clinical practice, correlation between several morphokinetic parameters and the prediction of implantation assists embryologists in the identification of top quality embryos. The rationale of TLM is incredibly fascinating. Although currently used in some clinical laboratories, the technique remains in the early stages of development and, as discussed in the review by Racowsky and Kaser, more data are necessary to confirm its clinically reliable use. Racowsky and Kaser highlight the need for additional prospective studies before TLM is adopted as a routine procedure in assisted reproduction.

Highlights July/August 2014

The dynamics of nuclear receptors and nuclear receptor coregulators in the pathogenesis of endometriosis in Hum. Reprod. Update (July/August 2014) Hum Reprod Update 2014;20:467-484

S.J. Han et al.

The article by Han and O'Malley in the July/August issue of the journal is the most complete review of genetic alteration, epigenetic variations and post-translational modification of nuclear receptors in endometriosis. Elucidation of these changes has identified possible new targets for the treatment of this oestrogen-dependent disease.

Highlights May/June 2014

Proceedings from the Third National Institutes of Health International Congress on Advances in Uterine Leiomyoma Research: comprehensive review, conference summary and future recommendations in Hum. Reprod. Update (May/June 2014) 20 (3): 309-333. doi: 10.1093/humupd/dmt058

James H. Segars et al.
In the latest issue of Human Reproduction Update the review by James Segars et al. discusses the newest investigations on uterine fibroids. The most common benign tumours in women, fibroids have a huge impact on reproductive function. This update reviews the most recent basic, translational and applied advances, associating them with an update on clinical management of the uterine fibroids. New medical and non-invasive, surgical treatment regimens are also discussed in great detail. 

Highlights March/April 2014

The relationship between gut and adipose hormones, and reproduction in Hum. Reprod. Update (March/April 2014) 20 (2): 153-174 doi:10.1093/humupd/dmt033 Alexander N. Comninos, Channa N. Jayasena and Waljit S. Dhillo The recent publication of Comninos et al., in the March/April issue of Human Reproduction Update describing the impact of gut and adipose tissue hormones on reproduction represents the best review on this topic in the scientific literature. The impact of undernutrition and obesity on fertility is of great clinical interest, influencing diagnosis and managment of infertility and sub-fertility. After 25 years of research it is very useful to summarize the mechanisms of action by which nutritional status influences reproductive function. 

Highlights January/February 2014

The transcriptome of follicular cells: biological insights and clinical implications for the treatment of infertility in Hum. Reprod. Update (January/February 2014) 20 (1): 1-11 first published online September 29, 2013 doi:10.1093/humupd/dmt044 by Elpida Fragouli, Maria D. Lalioti and Dagan Wells
The search from follicular cells of a valid indicator of oocyte maturity, the ability to generate a good quality embryo and the capacity to establish a pregnancy has great value. The transcriptome of granulosa cells and oocyte-surrounding cumulus cells may influence, and be influenced by, the oocyte; in the future, some of these genes may potentially represent clinically useful biomarkers The goal of determining oocyte competence based upon follicular cell assessment merits further investigation.