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    HEALTH OF ICSI CHILDREN
Content
 Introduction
Perinatal outcome and congenital malformation
Long-term medical outcome Neuro-developmental and psychological outcome Epigenetics and cancer
Reproductive health
Conclusion
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    PERINATAL OUTCOME
Prenatal tests in ICSI
       Bonduelle (2002)
% in reference population
p
Jozwiak (2004)
Number of foetusses
1586
1136
Karyotype anomalies
47
17
De novo: autosomes + sex
1.6%
15 +10
 0.45-0.87%
<0.001
1.2% 7 +7
Inherited
1.4%
22
 0.47%
<0.001
0.3% 3
TOTAL (95%CI)
2.96% (2.19‐3.92)
1.50% (0.87‐2.39)
            Bonduelle et al. Human Reprod. 2002, 17 (10): 2600-2614
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