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Introducing more Spermcomet Scores
Fertile men set a very high threshold
Unlike the heterogeneity of even a fertile man’s semen analysis,
most of their sperm have little DNA damage
Below these thresholds
• increased risk of infertility
• lower success rate by IVF
• lower success rate by ICSI
• increased risk of miscarriage
ESHRE PCC Andrology, Vienna, 2019
Using more SpermComet Scores to increase sensitivity
ACS = Average Comet Score (mean of all comets scored) LCS = Low Comet Score
HCS = High Comet Score
COMET PLOT FOR TYPICAL FERTILE MAN
25
LCS = 90% 20
15 10 5 0
ACS = 16%
HCS = 1%
COMET SCORE = DNA DAMAGE PER SPERM (%)
COMET PLOT FOR TYPICAL INFERTILE MAN
25
LCS = 59% 20
15 10 5 0
ACS = 32%
HCS = 9%
COMET SCORE = DNA DAMAGE PER SPERM (%)
Source: SpermComet fertile donor database (N= 76); SpermComet Unexplained database (N= 166) .
ESHRE PCC Andrology, Vienna, 2019
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PRECONGRESS COURSE 01 I VIENNA, AUSTRIA – 23 JUNE 2019 15
% SPERM IN EACH CATEGORY
% SPERM IN EACH CATEGORY