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Conclusion
 Fertility clinics and sperm/egg banks have a shared responsibility for the health of the children they help conceive.
 Sperm donors should therefore be screened for carrier status of common harmful mutations.
 However, it is overly demanding to state that there is a moral responsibility to rule out all possible genetic ‘defects’ in the offspring. The discrepancy between the uptake of preconception carrier screening in the general population and the demand that clinics and sperm/egg banks should screen comprehensively is disproportionate.
 We need more research on the views of well informed (!) patients and donors on comprehensive screening.
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References
Hansen A. Danish sperm donor passed neurofibromatosis on to five children. BMJ 2012;345:e6570.
Maron BJ, Lesser JR, Schiller NB, Harris KM, Brown C, Rehm HL. Implications of hypertrophic cardiomyopathy transmitted by sperm donation. JAMA 2009;302:1681–4.
Wirojanan J, Angkustsiri K, Tassone F, Gane LW, Hagerman RJ. A girl with fragile X premutation from sperm donation. Am J Med Genet A 2008;146:888–92.
Practice Committee of the American Society for Reproductive Medicine, Practice Committee of the Society for Assisted Reproductive Technology. Recommendations for gamete and embryo donation: a committee opinion. Fertil Steril 2013;99:47–62.
Sims CA, Callum P, Ray M, Iger J, Falk RE. Genetic testing of sperm donors: survey of current practices. Fertil Steril 2010;94:126–9.
Bell CJ, Dinwiddie DL, Miller NA, Hateley SL, Ganusova EE, Mudge J, et al. Carrier testing for severe childhood recessive diseases by next‐generation sequencing. Sci Transl Med 2011;3:65ra4.
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