Page 24 - ESHRE2019

How do we treat men with
double strand breaks
in their sperm?
If not by antioxidants, then how?.....
ESHRE PCC Andrology, Vienna, 2019
Detecting Double Strand Breaks using SpermComet
Ejaculates from fertile men
Ejaculates from infertile men
Testicular sperm
from fertile men (at vasectomy)
Testicular sperm from infertile men
n
76
95
10
27/63
DSB
7.5+/‐3.7
17.1+/‐1.0
‐‐‐‐‐‐‐‐
13.5+/‐6.2
ESHRE PCC Andrology, Vienna, 2019
DSB +SSB
14.8+/‐ 0.6
39.9+/‐ 1.3
13.2+/‐ 0.26
13.4+/‐3.9
51% DSB at ‘physiological levels’
DSB and SSB are both significantly higher
DSB+SSB of testicular sperm from infertile men is same as ejaculates from fertile men
22
18