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Impact of sperm DNA fragmentation on fertility
• Natural pregnancies (OR=7.01 [3.68‐13.36]) (Zini 2011)
• IUI (OR=9.9 [2.34‐41.51]) (Zini 2011; Bungum et al. 2007)
• IVF/ICSI : (Osman et al. 2015)
• IVF (RR=1.27 [1.05‐1.52]) • ICSI (RR=1.11 [1.00‐1.23])
• Miscarriage rate: (OR= 2.48 [1.54‐4.04]) (Rilcheva et al. 2016)
High Sperm DNA Fragmentation decreases live birth rates
Osman A, Alsomait H, Seshadri S, El‐Toukhy T, Khalaf Y. The effect of sperm DNA fragmentation on live birth rate after IVF or ICSI: a systematic review and meta‐analysis. Reprod Biomed Online. 2015 Feb;30(2):120‐7.
Lower sperm DNA fragmentation was associated with higher live birth rate
in IVF and ICSI.
OD=1.17 [1.07‐1.23]
18.8% 29.9%
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