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Sperm DNA integrity
• Infertilemen>fertilemen.
• Weaklyassociatedwithsemenparameters.
• Associated with poor pregnancy rates after IUI.
Large overlap of among patient groups
Men from couples with RPL
Infertile men with ≥ 1 impaired semen parameters Fertile men with normal semen parameters
SDF range (%)
Carlini et al. (2017) RBM Online 34(1), 58–65
DNA fragmentation and pregnancy/miscarriages after IVF/ICSI: a meta‐analysis.
 Pregnancy: 16 cohort studies (3,106 couples)
 Miscarriage: 14 cohort studies (965 pregnancies)  Pregnancy
– IVF:  with high DNA damage (OR 0.66; 95% CI 0.48– 0.90; P=.008)
– ICSI: no effect (OR 0.94; 95% CI 0.70–1.25; P=.65).  Miscarriage
– IVF : no effect (OR 1.84; 95% CI 0.98–3.46; P=.06).
– ICSI :  with high DNA damage (OR 2.68; 95% CI 1.40–
5.14; P=.003)
Zhao et al (2014) Fertil Steril 102(3) 998-1005
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Number of patients