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Juno‐Izumo interaction is required for fertilisation
 Izumo1‐deficient male mice are infertile. Sperm unable to fuse with eggs (Inoue et al. 2005)
Juno deficient female mice or ab‐blocking lead
to infertility and absence of fertilisation (Bianchi et al. 2014)
Juno is rapidly shed after fertilisation
 Cell surface Juno rapidly lost 40 min after fertilisation
 Juno redistributed to vesicles within the PVS within 1hr after fertilisation
 Eggs fertilised by ICSI or parthenogenetically‐activated retained Juno expression
Bianchi et al. 2014
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