Page 46 - ESHRE2019

Cohesin loss in oocytes explains aneuploidy
Chiang et al 2010 Curr Biol
Meiosis I division is unique
• SAC proteins assemble on kinetochores
• Inhibit APC during early part of meiosis I
• When microtubules attach to kinetochores the SAC switches off
• If you reduce SAC proteins you increase incidence of aneuploidy
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