Page 129 - ESHRE2019

Vanhie et al. – unpublished data
The panel of 42 miRNAs selected for validation
hsa-let-7a-5p hsa-miR-103a-3p hsa-miR-15b-5p hsa-miR-199b-5p hsa-miR-23a-3p hsa-miR-29b-3p
hsa-let-7b-5p
hsa-let-7c-5p*
hsa-let-7d-5p
hsa-let-7e-5p
hsa-let-7f-5p
hsa-miR-101-3p
hsa-miR-106a-5p
hsa-miR-107
hsa-miR-10a-5p*
hsa-miR-125b-5p
hsa-miR-148a-3p*
hsa-miR-15a-5p
hsa-miR-16-5p
hsa-miR-17-3p*
hsa-miR-17-5p
hsa-miR-182-5p*
hsa-miR-18a-5p
hsa-miR-199a-5p
hsa-miR-19a-3p
hsa-miR-19b-3p
hsa-miR-20a-5p
hsa-miR-21-5p*
hsa-miR-210-3p*
hsa-miR-22-3p
hsa-miR-24-3p
hsa-miR-25-3p
hsa-miR-26a-5p
hsa-miR-26b-5p
hsa-miR-28-5p
hsa-miR-29a-3p
hsa-miR-30a-3p*
hsa-miR-30a-5p*
hsa-miR-33a-5p
hsa-miR-92a-3p
hsa-miR-95-3p
hsa-miR-98-5p
Vanhie et al – Unpublished data
Vanhie et al. – unpublished data
Model 1: All endometriosis stages
Intercept
hsa-let-7d-5p
hsa-miR-21-5p
Intercept
hsa-miR-125b-5p
hsa-miR-28-5p
Intercept
hsa-miR-21-5p
hsa-miR-28-5p
hsa-miR-30a-5p
Coefficient SE P-Value
1.000 0.236 <0.0001
3.219 1.363 0.0182
-3.758 1.093 0.0006
0.321 0.271 0.2370
3.551 1.221 0.0036
11.356 3.431 0.0009
0.198 0.271 0.4664
-4.794 1.357 0.0004
11.343 3.270 0.0005
6.874 2.610 0.0084
Optimal cut-off
0.5556 
 specificity: 49%
 AUC: 77% (66-87%)
 AUC: 81% (71-90%)
Diagnostic performance
 AUC: 73% (64-83%)
hsa-miR-28-5p 5.967 2.473 0.0158
Model 2: Stage I-II endometriosis Coefficient SE P-Value Optimal cut-off Diagnostic performance
0.4759 
 specificity: 62%
Sensitivity: 85%
Sensitivity: 80%
hsa-miR-29a-3p -6.906 2.030 0.0007
Model 3: Stage III-IV endometriosis Coefficient SE P-Value Optimal cut-off Diagnostic performance
0.6247 
 specificity: 89%
Sensitivity: 63%
Vanhie et al – Unpublished data
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