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Proteomic and metabolomic approaches for biomarker discovery
proteomics non‐targeted
metabolomics
targeted
multiplex assays protein arrays LC‐MS/MS
2D‐PAGE‐MS/MS DIGE‐MS/MS
MALDI TOF‐MS LC‐MS/MS
targeted
LC‐MS/MS NMR
non‐targeted
LC‐MS/MS NMR
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Proteomics – mass spectrometry
Savino et al. 2012
MALDI‐TOF‐MS
comparison of protein profiles
LC‐MS/MS
protein identification
2D‐PAGE‐MS/MS DIGE‐MS/MS
protein identification
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