Page 186 - ESHRE2019

Blood biomarkers for endometriosis CA‐125
Cut-off
Sensitivity
95% CI
Specificity
95% CI
>10.0 - 14.7
0.70
0.63, 0.77
0.64
0.47, 0.82
Cut-off
Sensitivity
95% CI
Specificity
95% CI
>16.0 - 17.6
0.56
0.24, 0.88
0.91
0.75, 1.00
Cut-off
Sensitivity
95% CI
Specificity
95% CI
>20
0.67
0.50, 0.85
0.69
0.58, 0.80
Cut-off
Sensitivity
95% CI
Specificity
95% CI
>25.0 - 26.0
0.73
0.67, 0.79
0.70
0.63, 0.77
Cut-off
Sensitivity
95% CI
Specificity
95% CI
>30.0-33.0
0.62
0.45, 0.79
0.76
0.53, 1.00
Cut-off
Sensitivity
95% CI
Specificity
95% CI
>35.0-36.0
0.40
0.32, 0.49
0.91
0.88, 0.94
Nisenblat et al., Cochrane Database Syst Rev 2016
Blood biomarkers for endometriosis
Of the biomarkers that were subjected to meta‐analysis, none consistently met the criteria for a replacement or triage diagnostic test.
A subset of blood biomarkers could prove useful either for detecting pelvic endometriosis or for differentiating ovarian endometrioma from other benign ovarian masses, but there was insufficient evidence to draw meaningful conclusions.
Nisenblat et al., Cochrane Database Syst Rev 2016
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