Page 18 - ESHRE2019

Age impacts recovery after ABVD
By age 150
100 50 0
By median AMH (9.8 pmol/l) 140
Age <35
P<0.0001
Age 35+
120
100
80
60
40
20
0
Abo1ve
Bel2ow
ns
Different to breast cancer data: older population, more toxic treatment?
MRC Centre for Reproductive Health at the University of Edinburgh
Anderson RA et al 2018 Lancet Oncol
Multiple linear regression analysis vs AMH recovery: age (beta ‐0.43, p=0.004)
pretreatment AMH (beta ‐0.15, p=0.3)
Ovarian stroma and vasculature are damaged by chemotherapy
Normal control
After chemotherapy
Green: Masson stain for collagen
MRC Centre for Reproductive Health at the University of Edinburgh
Focal cortical fibrosis in ovaries exposed to chemotherapy
Prominent thickening and hyalinization, with narrowing /obliteration of the lumen
Meirow D et al. Hum. Reprod. 2007;22:1626-1633
16
13
% recovery