Page 120 - ESHRE2019

Antiphospholipid antibodies
aPL
aPL harm trophoblast
1st trimester miscarriages
Intrauterine death
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2nd & 3rd trimester: fetal growth restriction, 10% pre‐ eclampsia, placental abruption, premterm delivery
s Inflammation
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Mouse model implicates
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Obstetric Antiphospholipid syndrome
= Persistent aPL + obstetric complications
• Recurrent pregnancy loss < 10 weeks of gestation
• Pregnancy loss ≥10 weeks of gestation
• Prematurity < 34 weeks of gestation due to ischemic placental insufficiency
• Ischemic placental insufficiency can also result in fetal growth restriction (FGR), preeclampsia, eclampsia, placental abruption,
HELLP syndrome & fetal death
Miyakis JTH 2006
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