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Variation in mosaicism – patients and clinics
• 17,645 TE samples assessed via NGS, 31 IVF clinics
• PGT-A indication effect on mosaicism: 2,285 TE samples assessed
Embryos generated by 378 couples Indications: ARA, RM, RIF
• Biopsy practitioner effect on mosaicism:
1,949 TE samples assessed
Embryos generated in 8 IVF clinics
Mosaicism rates calculate for 24 embryologists
• Culture/ embryo handling effect on mosaicism: 13,411 TE samples assessed
Embryos generated in 23 IVF clinics
18%
Euploid Mosaic Abnormal
62%
ARA
20%
25%
Euploid Mosaic Abnormal
49%
RM
26%
24%
Euploid Mosaic Abnormal
46%
RIF
30%
Results- PGT-A indication & mosaicism
• Mosaicism rate for 2,285 blastocysts generated by 378 couples
• ARA: 171 couples (average female age 40.6 years)/ 956 blastocysts RM: 79 couples (average female age: 37.5 years)/ 523 blastocysts RIF: 128 couples (average female age: 36.3 years)/ 806 blastocysts
• RM & RIF generated more mosaic blastocysts vs. ARA (P= 0.0069)
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