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Learning Objectives
Significance?
What is the fate?
How do aneuploid cells adopt this fate?
Assessment of embryo vitality in the IVF clinic
Aneuploidy in early human embryogenesis
Zygote 2 cell 4 cell
Low fecundity in humans
Early Expanded blastocyst blastocyst
0.6% Live Births Implantation
~70%
Mosaicism
8 cell 16 cell
Mosaic Aneuploidy
Aneuploid cells Diploid cells
Clinical Miscarriage Implantation Failure ~30%
Conceptions
Live Births 30%
Macklon N. S., et al. (2002)
van Echten-Arends, et al. (2011)
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PRECONGRESS COURSE 10 I VIENNA, AUSTRIA – 23 JUNE 2019 27
