Page 99 - ESHRE2019

Mosaicism and age
Does mosaicism change with advancing female age?
Age
Embryos analyzed
Euploid
Aneuploid
All mosaics
Mosaics containing euploid cells
<35
2363
48.20%
18.60%
33.20%
26.60%
35-37
1572
43.90%
26.40%
29.80%
20.50%
38-40
1526
33.10%
35.60%
31.40%
17.90%
41-42
689
17.00%
51.60%
31.40%
13.90%
>42
436
10.60%
57.60%
31.70%
10.50%
80 60 40 20
0
Mosaic Aneuploid
<35
35-37
38-40
41-42 >42
Do mosaic biopsy results reflect ICM status?
If a trophectoderm biopsy is mosaic, what is the status of the inner cell mass?
Initial NGS Diagnosis
Total Embryos
Euploid ICM
Full Aneuploidy
19
0/19 (0%)
Full Segmental
3
0/3 (0%)
Mosaic Complex
12
2/12 (17%)a
Mosaic Segmental
15
8/15 (53%)b
Mosaic Full Aneuploidy
16
8/16 (50%)c
a vs. b+c: p<0.05
94
PRECONGRESS COURSE 10 I VIENNA, AUSTRIA – 23 JUNE 2019 97
Percentage embryos affected