Page 70 - ESHRE2019
P. 70
Learning Objectives
Chromosomal instability in human pluripotent stem cells:
• Type and frequency of chromosomal abnormalities in hiPSCs and hESCs
• Mechanisms leading to chromosomal instability hPSCs
• Culture heterogeneity
• Exogenous effects on chromosomal stability • Implications for clinical applications
• Culture-adapted hPSCs often exhibit increased proliferation capacity and decreased growth factor dependence
• Often form more aggressive malignant tumours when injected into mice
• Genes that reside in the recurrent aberrant regions have been suggested to contribute to the selective advantage
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