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References
• Weissbein et al. Genome-wide Screen for Culture Adaptation and Tumorigenicity-Related Genes in Human Pluripotent Stem Cells. iScience 11 (2019): 398-408.
• Draper et al. Recurrent gain of chromosomes 17q and 12 in cultured human embryonic stem cells. Nat Biotechnol, 2004. 22(1): p. 53-4.
• Amps et al. Screening ethnically diverse human embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantage. Nat Biotechnol, 2011. 29(12): p. 1132-44
• Taapken et al., Karyotypic abnormalities in human induced pluripotent stem cells and embryonic stem cells. Nat biotechnol, 2011. 29(4): p. 313-314.
• Lefort et al. Human embryonic stem cells reveal recurrent genomic instability at 20q11.21. Nat Biotechnol, 2008. 26(12): p. 1364-6.
• Romero-Lanman et al. Id1 maintains embryonic stem cell self-renewal by up-regulation of Nanog and repression of Brachyury expression, Stem cells and development 21.3 (2011): 384-393.
• Nguyen et al. Gain of 20q11. 21 in human embryonic stem cells improves cell survival by increased expression of Bcl-xL, Molecular human reproduction 20.2 (2013): 168-177.
• Spits et al. Recurrent chromosomal abnormalities in human embryonic stem cells. Nat biotechnol 26.12 (2008): 1361.
• Elliott et al. High resolution array-CGH characterization of human stem cells using a stem cell focused microarray, Molecular biotechnology 46.3 (2010): 234-242.
• Knoepfler. Deconstructing stem cell tumorigenicity: a roadmap to safe regenerative medicine. Stem cells 27.5 (2009): 1050-1056.
• Holubcova et al. Human embryonic stem cells suffer from centrosomal amplification. Stem Cells 29, 46–56 (2011).
• Mayshar et al. Identification and classification of chromosomal aberrations in human induced pluripotent stem cells. Cell Stem Cell 7, 521–531 (2010).
• Jacobs et al. Low-grade chromosomal mosaicism in human somatic and embryonic stem cell populations. Nature communications 5 (2014): 4227.
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• Jacobs et al. Higher-density culture in human embryonic stem cells results in DNA damage and genome instability. Stem Cell Reports 6.3 (2016): 330-341.
Björn Heindryckx Petra De Sutter
Kelly Tilleman
Margot Van der Jeught
Cooperations
Sharat Warrier
UGent:
Davina Bonte
Ramesh Reddy Guggilla Maoxing Tang
Vanessa Thys
Lien Dhaenens
Chloë De Roo
Swati Mishra Panagiotis Stamatiadis Stefanie De Gheselle Ilse Decroo
Sylvie Lierman
Bieke Bekaert
Antonia Christodoulaki Athina Karamouza
D. Deforce/F. Van Nieuwerburgh
Jasin Taelman
B. Menten/P. Coucke/J. Van de Sompele/E. De Baere
R. Van Coster
F. Speleman
A. Van Soom/L. Peelman L. Leybaert
S. Chuva de Sousa Lopes (Leiden) K. Coward (Oxford)
J. Parrington (Oxford)
International:
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