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Difference from mouse TS
FGF↑ Wnt↓ TGF‐↑ ROCK↓
Mouse TS cells
Cdx2, Eomes, Elf5
Esrrb, Ets2, Gata3 Sox2, Tead4, Tfap2c
EGF↑ TGF‐↓ Wnt↑ HDAC↓ ROCK↓
Human TS cells
CDX2, EOMES, ELF5
ESRRB, ETS2, GATA3 SOX2, TEAD4, TFAP2C
Signaling pathways
Transcription factors
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Clinical Applications
● Disease TSCs (Pathology, Biomarkers, Development of treatment) ● Support of implantation (Assisted Reproductive Technologies)
● Immune tolerance (Regenerative Medicine)
● Bioactive substance (Placental Hormones)
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