Page 98 - ESHRE2019

Key Concepts
• Insulin signaling is relevant to normal reproductive physiology
• Insulin resistance plays a mechanistic role in endocrinology and metabolic profile of PCOS
• In women with PCOS anticipating proceeding with IVF, considerations for pre IVF use of insulin sensitizers include:
Pros
Cons
Reduced risk of OHSS +++
GI disturbances +++
Improved clinical pregnancy? ++/--
Cost?? -
Reduced risk of miscarriage? +/-
Reduced risk of late loss/PTD? +/-
Reduced risk of GDM? +/-
SLIDE 20
Learning Objectives
At the conclusion of this presentation, participants should be gain familiarity with:
1. 2. 3. 4.
Concept of insulin resistance & insulin sensitivity
Relevance of IR to endocrinology & pathophysiology of PCOS
Mode of action of common insulin sensitizers (M&M’s- Metformin, Myoinositol) Role of IS in Pre IVF Management – considerations, rationale & approaches
SLIDE 21
96
93