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ALIFE2 Study design Primary efficacy outcome: Live birth
Confirmed Inherited thrombophilia
Recruitment ®
delivery
Follow-up
6 weeks
LMWH +
standard pregnancy surveillance
MM
≥ 2 miscarriages and/or IUFDs
Positive urine pregnancy test
Standard pregnancy surveillance
Aspirin
Take home messages
For APS and recurrent miscarriage
For women with a history of preeclampsia
Heparin
For APS and recurrent miscarriage (weak evidence, absent for LMWH)
For inherited thrombophilia: include in ALIFE2 Nobody knows in APS and late complications!
Do NOT use in all others
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PRECONGRESS COURSE 05 I BARCELONA, SPAIN – 1 JULY 2018 125