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Unexplained recurrent miscarriage
Kaandorp, NEJM 2010
No effect of aspirin and LMWH (RR 1.03, 0.85-1.25) No effect of aspirin (RR 0.92, 0.75-1.13)
In women with thrombophilia: Aspirin and LMWH (RR 1.31, 0.74-2.33) No effect of aspirin (RR 1.22, 0.69-2.16)
ALIFE2: In‐/exclusion criteria
Inclusion criteria:
• ≥2 miscarriages and / or IUFDs
• Age 18‐42
• Confirmed inherited thrombophilia:
• Factor V Leiden mutation, prothrombin gene mutation, protein C deficiency, protein S deficiency, antithrombin deficiency
Exclusion criteria:
• Pregnancy duration ≥7 weeks
• Indication for anticoagulant treatment during pregnancy (for instance prosthetic heart valves, a history of venous thromboembolism or antiphospholipid syndrome)
• Contraindications to LMWH
• Known allergy to at least 3 different LMWH preparations • Previous inclusion in the ALIFE2 study
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