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What we learned......
• Monosomy blastocysts often do not successfully implant and are compromised compared to euploid and trisomy for:
• hypomethylation on the chromosome of error • global transcriptome
• key developmental genes
• The transcriptome of trisomy blastocysts is also compromised compared to euploid but to a lesser extent in trisomy 15 blastocysts than in trisomy 11.
• Transcriptional dosage compensation of trisomy 15 embryos could explain their observed implantation potential.
McCallie et al, 2016
Could genomic imprinting also be implicated in the differential implantation potential observed among aneuploid blastocysts?
Genomic imprinting is a epigenetic phenomenon restricting expression to the maternal OR paternal allele
Monoallelic Genes
Biallelic Genes
Maternally Expressed
Paternally Expressed
Maternally Expressed
Paternally Repressed
Maternally Repressed
Paternally Expressed
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PRECONGRESS COURSE 08 I BARCELONA, SPAIN – 1 JULY 2018 59
