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Function
HLA products are involved in T lymphocyte antigen presentation and help the immune system to distinguish the body's own proteins from proteins made by foreign invaders such as viruses and bacteria
Key function in immune activation and regulation... - Infectious disease
- Autoimmunity
- Cancer immunology - Transplantation
Main barrier in solid organ and hematopoietic stem cells transplantation
HLA typing is of great significance for basic and translational research (relative risk assessment in HLA-associated diseases, adverse drug reactions, population
studies...)
HLA genotypes are used to match donors and recipients during transplantation to reduce the risk of transplant rejection and general transplant complications.
Nomenclature: Serology vs Molecular Typing
Serology
• Ab reagents DR4
Molecular
• DNA amplification DRB1*0401
DRB1*0402 DRB1*0403 DRB1*0404
DRB1*0405... DRB1*0424
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PRECONGRESS COURSE 10 I BARCELONA, SPAIN – 1 JULY 2018 27