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 Human Sperm Bind* to huZP2 Rescue Zona huZP1 Rescue huZP2 Rescue
Hu Mo 11 22 33 44
Hu Mo Hu Mo 11 22 33 44
  Hu Mo
      huZP3 Rescue huZP4 Transgenic
*but do not fertilize
 Control
Zp2 Null
trefoil
Mouse Transgenesis: Loss of Function
   ZP1 Disulfide Bonds
Zona domain (A)
  ZP2 Disulfide Bonds
Zona domain (A)
  Zona domain (B) ZP3
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