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   Mosaic epiblast development during implantation in vitro Diploid - Diploid
chimera
Diploid - Aneuploid mosaic chimera
Immunosurgery
72 hours
                             Reversine Diploid - Diploid
Time
Diploid - Aneuploid
Time
EPI cells (%) 61.3
Diploid
Diploid 27.8 Aneuploid
                   Diploid
                    Aneuploid cells are preferentially eliminated from mosaic epiblast during implantation
Apoptosis of aneuploid cells in mosaic epiblast during implantation
Reduced in vitro culture system (without TE)
Diploid - Aneuploid
               Reversine
           Diploid - Aneuploid
Time
                                      mTomato H2B-GFP mTomato H2B-GFP mTomato H2B-GFP
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